TTK promotes mesenchymal signaling via multiple mechanisms in triple negative breast cancer

Increase in TTK expression and its correlation with higher tumor grade, triple negative status, and worse overall survival in breast cancer. a–d Box plots of TTK gene expression across tumor grades (a), between ER-positive and ER-negative breast cancers (b), across Pam50 subtypes of tumors (c), and across different subtypes in breast cancer cell lines from the GOBO database (d). e Box plots comparing TTK z-scores between TNBCs and non-TNBCs from patients in the TCGA database. f Kaplan–Meier survival analysis illustrating the correlation between higher TTK expression and decreased overall survival in breast cancer patients from the BreastMark databas