TNF ROCKs the boat as the kidney endothelium springs a leak

Abnormal vascular permeability is a hallmark of sepsis‐mediated injury to various organs. An intact endothelial barrier is critical to homeostasis and prevents leakage of abnormal quantities of fluid and protein, including proinflammatory cytokines and chemokines, into the extravascular space. Barrier disruption leads to distributive shock as well as organ dysfunction and edema (Lee and Slutsky 2010)