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-  2018 

Genetic polymorphism of the methotrexate transporter ABCG2, blood pressure and markers of arterial function in patients with rheumatoid arthritis: repeated cross-sectional study

DOI: 10.2147/PGPM.S170557

Keywords: methotrexate, disease-modifying antirheumatic drugs, blood pressure, augmentation index, rheumatoid arthritis, pulse wave velocity, single-nucleotide polymorphisms, ATP-binding cassette transporters, ABCG2

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Abstract:

Methotrexate (MTX) treatment is associated with lower blood pressure (BP) and arterial stiffness in rheumatoid arthritis (RA). We investigated associations between single-nucleotide polymorphism (SNP) of the ATP-binding cassette efflux transporter gene ABCG2 (rs2231142), BP, and arterial stiffness in RA patients treated with MTX

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