Abstract QS7: Minimally Processed Adipose-Derived Stem Cells Increase Union Rates, Vascularity, and Cellularity During Fracture Repair of the Irradiated Murine Mandible

PURPOSE: Vascular and cellular depletion secondary to radiotherapy represents a major clinical challenge in mandibular reconstruction. Adipose-derived stem cells (ASCs) represent a promising component of regenerative medicine due to their multipotent potential and relative ease of harvest, yet remain under-investigated in the setting of radiotherapy. Furthermore, clinical translation of ASCs is currently impeded by arduous processing techniques and FDA regulations surrounding cell culture. This investigation examines the ability of minimally-processed ASCs (MPASCs) to enhance irradiated bone healing during fracture repair in the murine mandible to further delineate translatable methods of efficient ASC administration that ultimately expand the use of cell-based therapeutics in craniofacial reconstruction