The emerging role of geropathology in preclinical aging studies

In 2015, the United States National Institute on Aging funded the Geropathology Initiative, designed to develop a systematic approach for using the pathology of aging as a way to assess anti-aging interventions. As a result, the Geropathology Research Network was formed, consisting of various working groups composed of experts in anatomic pathology, molecular pathology, and translational geroscience. Within the Anatomic Pathology Working Group, a Geropathology Grading Committee was formed for the purpose of developing guidelines for a scoring system based on the increasing severity of lesions associated with increasing age, using the mouse as the preclinical prototype model