Abnormal neurite density and orientation dispersion in unilateral temporal lobe epilepsy detected by advanced diffusion imaging
DOI: 10.1016/j.nicl.2018.09.017
Keywords: Temporal lobe epilepsy , Neurite orientation dispersion and density imaging , Diffusion MRI , MRI-negative focal epilepsy , Hippocampal sclerosis AEDs , Anti-epileptic drugs , TLE , Temporal lobe epilepsy , HS , Hippocampal sclerosis , FDG-PET , 18F-fluorodeoxyglucose positron emission tomography , MRI-/PET+ , MRI-negative/PET-positive , dMRI , Diffusion MRI , NODDI , Neurite orientation dispersion and density imaging , ICVF , Intracellular volume fraction , ODI , Orientation dispersion index , RSI , Restriction spectrum imaging , FA , Fractional anisotropy , MD , MEAN DIFFUSIVITY , EEG , Electroencephalogram , FSL , FMRIB Software Library , SPM , Statistical parametric mapping , DARTEL , Diffeomorphic anatomical registration using the exponentiated lie , TBSS , Tract-based spatial statistics , ROI , Region of interest , JHU , Johns Hopkins University
Abstract:
Despite recent advances in diffusion MRI (dMRI), there is still limited information on neurite orientation dispersion and density imaging (NODDI) in temporal lobe epilepsy (TLE). This study aimed to demonstrate neurite density and dispersion in TLE with and without hippocampal sclerosis (HS) using whole-brain voxel-wise analyses
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