Reduced sound-evoked and resting-state BOLD fMRI connectivity in tinnitus
DOI: 10.1016/j.nicl.2018.08.029
Keywords: Tinnitus , ABR wave , fMRI , r-fcMRI , Cortisol ABR , auditory brainstem response , BA , Brodmann area , BA13P , posterior insula , BA13A , anterior insula , BA28 , entorhinal cortex , BB-chirp , broadband chirp , BERA , brainstem-evoked response audiometry , CN , cochlear nucleus , CSF , cerebrospinal fluid , DL , dorsolateral , EFR , envelope-followed responses , ENT , ear , nose and throat , FA , flip angle , FDR , false discovery rate , FOV , field of view , FWHM , full width at half maximum , G-H-S , Goebel-Hiller-Score , HF-chirp , high-frequency chirp , High-SR AF , high-spontaneous firing rates auditory fibers , HPA , hypothalamic-pituitary-adrenal , IC , inferior colliculus , L , left , LF-chirp , low-frequency chirp , Low-SR AF , low-spontaneous firing rates auditory fibers , M , medial , MGB , medial geniculate body , MNI , Montreal Neurological Institute , PFC , prefrontal cortex , PTA , pure tone audiogram , R , right , rCBF , resting-state cerebral blood flow , rCBV , resting-state cerebral blood volume , ROI , region of interest , SD , standard deviation , SOC , superior olivary complex , SPL , sound pressure level , SPM , Statistical Parametric Mapping , TA , acquisition time , TE , echo time , TR , repetition time , VBM , voxel-based morphometry , zFC , z-values functional connectivity
Abstract:
The exact neurophysiological basis of chronic tinnitus, which affects 10-15% of the population, remains unknown and is controversial at many levels. It is an open question whether phantom sound perception results from increased central neural gain or not, a crucial question for any future therapeutic intervention strategies for tinnitus
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