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-  2018 

Tractography-assisted deep brain stimulation of the superolateral branch of the medial forebrain bundle (slMFB DBS) in major depression

DOI: 10.1016/j.nicl.2018.08.020

Keywords: Deep brain stimulation, Depression, Diffusion tensor imaging, Fiber tracking, Medial forebrain bundle, OCD, slMFB, Stereotactic surgery, Tractography CT, computed tomography, DBS, deep brain stimulation, DTI, diffusion tensor magnetic resonance imaging, DTI FT, DTI fiber tractography, EC, effective contact, FT, fiber tractography, HF, high frequency, Hz, Hertz [1/s], IPG, internal pulse generator, mA, milli-ampere, MADRS, Montgomery-?sberg Depression Rating Scale, MCP, mid-commissural point, MDD, major depressive disorder, MRI, magnetic resonance imaging, RN, red nucleus, STN, subthalamic nucleus, SNr, substantia nigra pars reticulata, VAT, volume of activated tissue, VTA, ventral tegmental area, μs, micro second

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Abstract:

Deep brain stimulation (DBS) of the superolateral branch of the medial forebrain bundle (slMFB) emerges as a - yet experimental - treatment for major depressive disorder (MDD) and other treatment refractory psychiatric diseases. First experiences have been reported from two open label pilot trials in major depression (MDD) and long-term effectiveness for MDD (50?months) has been reported

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