Transcriptional and functional consequences of TP53 splice mutations in colorectal cancer

a Proportion of TP53 mutation types, plotted as the percentage of the total number of detected mutations (N？=？252). b Frequency and distribution of TP53 splice (red) and exon (gray) mutations at each position along the gene (codon number is indicated below). The frequency is calculated relative to all mutations included in this plot (N？=？236; exon mutations encompassing multiple codons, i.e. indels, are excluded). Frequency of splice mutations represents all mutations affecting the relevant splice region; see Table Table11 for details. TAD transactivation domain, PRD proline-rich domain, DBD DNA-binding domain, NLS nuclear localization domain, OD oligomerization domain, Neg negative-regulation domai