Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma

a Endogenous ASS1 was found in H520 and SW900 xenografts while ARG2 was highly expressed in H520 xenografts. Protein expression levels of H520 and SW900 were compared with SK-MES-1 xenograft. Data represent the mean？±？standard error of the mean (SEM) (N？=？3) was analyzed using one-way analysis of variance (ANOVA) by Prism. BCT-100 inhibited tumor growth in b SK-MES-1 and c SW900, but not d H520 xenografts. Data represent the mean？±？SEM (N？=？6), and was analyzed using repeated measure ANOVA by Prism. A p value？<？0.05 defined statistical significance (*p？<？0.05, **p？<？0.01, ***p？<？0.001