CARF enrichment promotes epithelial–mesenchymal transition via Wnt/β-catenin signaling: its clinical relevance and potential as a therapeutic target

a Percentage CARF amplification in clinical cancer datasets in TCGA database. b Enrichment of CARF mRNA levels in invasive and metastatic malignancies; RNA-Seq (V2 algorithm) expressions in log10 scale. c CARF-gene amplification in metastatic breast cancer cell lines (upper); values represented as fold enrichment (lower). d Dot plot showing percentage amplification of candidate genes (shortlisted in TCGA-defined invasion/metastases and angiogenesis gene sets) in patients with (n？=？10) and without (n？=？97) CARF amplification in NEPC (2016) datase