Mapping connections in signaling networks with ambiguous modularity

Reaction scheme of the MEK/ERK cascade model studied by Parabakaran et al.20 Reaction rates are described by mass action kinetics, the appropriate rate constants are indicated at the arrows. Species of the MEK module are indicated in blue, species of the ERK module are indicated in red. Communicating species are selected as the sums of species in shaded parallelograms (Eq. 9)2