The gravity dependence of pharmacodynamics: the integration of lidocaine into membranes in microgravity

a Normalized data of the changes in fluorescence polarization (FP) of the microgravity experiment and 1g ground reference. In both cases, upon addition of 16？mM lidocaine (start of mixing is indicated by arrow; mixing indicated by #2; artifacts caused by moving air bubbles are marked by #1), FP decreased. A reduced FP indicates a decrease in membrane viscosity or an increase in membrane fluidity. It is visible that, during microgravity, the increase membrane fluidity is less compared to 1g. The big spike was caused by the high g-load (24.2g) during the deployment of parachute. One datapoint (second 428) during the deployment was removed as an artifact due to the mechanical shock. b FP flight data compared to the acceleration profile (vector addition of all three axes x, y, and z). At the end of the flight, the average gravity increases again, the big spike indicates the opening of the parachute. With onset of gravity, FP slightly increased again. The dotted lines indicate 0g and 1