The making of a miscreant: tobacco smoke and the creation of pathogen-rich biofilms

Hierarchical circle packing plot of transcriptional activity in commensal (a) and pathogen-rich (b) biofilms. Each circle represents a gene and is sized by log2 fold change. Genes are grouped based on their functional roles based on SEED classification. Genes that were significantly over-expressed (log2 fold change >2, p？<？0.05, FDR-adjusted Wald test) in a smoke-rich environment when compared to controls are in red, while those that were under-expressed following smoke conditioning are shown in gray. White circles indicate genes whose change in expression did not meet the above criteria. The data used in creating this Figure are shown in Supplementary Table