Metagenomic and metatranscriptomic analysis of saliva reveals disease-associated microbiota in patients with periodontitis and dental caries

Microbial diversity. a: Rarefaction curves expressed as number of reads assigned at species level (x-axis) and α-diversity (observed Species and Shannon index, y-axis) of salivary microbiota characterized using metagenomics and metatranscriptomics. b: Distribution of α-diversity among groups presented as boxplot (median, lower/upper quartile and standard deviation). c: β-diversity determined by Bray-Curtis dissimilarity and plotted using PCoA. Sample denotation: green: healthy controls, blue: dental caries, red: periodontiti