Lysophosphatidic acid LPA1 and LPA3 receptors play roles in the maintenance of late tissue plasminogen activator-induced central poststroke pain in mice

DOI: 10.1016/j.ynpai.2018.07.001

Keywords: CPSP, central post-stroke pain, NeuP, neuropathic pain, MCA, middle cerebral artery, PIT, photochemically induced thrombosis, tPA, tissue-type plasminogen activator, LPA1, lysophosphatidic acid receptor 1, LPA3, lysophosphatidic acid receptor 3, LC–MS/MS, liquid chromatography–mass spectrometry, MD, medial dorsal thalamus, LPA1-KO, LPA1-deficient, pSNL, partial sciatic nerve ligation, RB, Rose Bengal, i.v., intravenously, TTC, 2,3,5-triphenyltetrazolium chloride, PFA, paraformaldehyde, HE, Hematoxylin and Eosin, EPW, electrical stimulation-induced paw withdrawal, PWL, paw withdrawal latency, DMSO, dimethyl sulfoxide, MRM, multiple reaction monitoring, S-I, sensory cortex, tMCAO, transient middle cerebral artery occlusion Central poststroke pain, Lysophosphatidic acid, LC–MS/MS, Photochemically induced thrombosis, tPA

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