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-  2017 

Habituation as an adaptive shift in response strategy mediated by neuropeptides

DOI: 10.1038/s41539-017-0011-8

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Abstract:

Habituation of glutamate transmission mutants reveals a glr-1 mutant phenotype. a Representative raster plots depicting the behavioral state at the beginning (left) and end (right) of training. Pixels are color coded for speed with negative values corresponding to backward locomotion. Black bars indicate 2?s of whole-plate illumination with blue light at 250?μW/mm2. b, c Proportion of the population reversing to each of thirty 2?s light pulses administered at 0.1?Hz. b The glr-1-independent response did not persist across the assay, c but could be rescued with a GLR-1 expressing transgene (GLR-1::GFP) or suppressed by loss of egl-3. Mean?±?SEM. ‘#’, ‘¥’, and ‘&’ denote groups that are statistically different based on the likelihood of responding to the final stimulus. N?=?6 plates/strai

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