Non-coding RNAs as Emerging Regulators of Neural Injury Responses and Regeneration

Schematic diagram illustrating (1) the joint inhibitory effects of miR-21 and miR-222 on neuronal apoptosis through suppressing TIMP3 after peripheral nerve injury, and (2) the promoting effects of miR-21 and miR-222 on neurite regrowth through suppressing sprouty2 and PTEN, respectively, after peripheral nerve injury. T-shaped lines indicate an inhibitory effect or negative regulation while arrows indicate a promoting effect