Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast

Immunohistochemical analysis of p53 and PTEN in MBCs. Representative micrographs of metaplastic breast carcinomas (MBCs), a with spindle cell (META32) and b-d with squamous metaplasia (META41, META37, and META42, respectively). Immunohistochemical analysis showed loss of PTEN expression in e META32 and f META41 and p53 overexpression in g META37 and h META42. In e and f, note the positive internal control for PTEN in blood vessels. Scale bars, 100？μ