The AURORA pilot study for molecular screening of patients with advanced breast cancer–a study of the breast international group

Logistics and feasibility of the study. a logistic workflow of the study, b inclusion criteria and number of patients with successful results, c anatomical distribution of biopsied lesions with breakdown by recruiting centre, d global distribution of patients by recruiting centre, e turnaround time for each patient with breakdown by recruiting centre, f median global turnaround time by recruiting centre, and g median delivery turnaround time by recruiting centre. In a, the Illumina sequencing and Affymetrix OncoScan SNP arrays were done as batch processes. 19 patients were sequenced by Illumina targeted NGS and 18 patients were genotyped using the Affymetrix SNP arrays. However, these are not fully overlapping subsets and only 14 (54%) patients had the full set of all three data types. In a and b, the Ion Torrent sequencing results were obtained in real-time and in (e), the darker shades indicate delivery turnaround time (TAT) whilst the lighter shades indicate global turnaround time. The colour codes for the recruiting centres in c to g are indicated in (d