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- 2019
Longitudinal analysis of structural changes following unilateral focused ultrasound thalamotomyDOI: 10.1016/j.nicl.2019.101754 Keywords: Focused ultrasound, Thalamotomy, Tractography, Free water correction, Lesion characteristics dMRI, diffusion MRI, RDI, Restricted Diffusion Imaging, FA, Fractional Anisotropy, AD, Axial Diffusivity, RD, Radial Diffusivity, MD, Mean Diffusivity, TFCE, Threshold-Free Cluster Enhancement, QSDR, q-space diffeomorphic reconstruction algorithm, ANTs, Advanced Normalization Tools, FUS-T, Focused Ultrasound thalamotomy, SDF, spin diffusivity function, NQA, normalized quantitative anisotropy, ODF, orientation distribution function, ET, Essential Tremor, DTI, Diffusion Tensor Imaging, DWI, Diffusion-weighted imaging, ROC, Receiver operator characteristics Abstract: Focused ultrasound thalamotomy is an emerging treatment for essential tremor, and it is ideal for studying reorganization in the human brain after acute injury because it creates a controlled thalamic ablation without breaching the cortex. However, there is not yet a metric capable of detecting microstructural changes in the presence of acute phase edema with good sensitivity in the chronic phase, when the lesion boundaries become inconspicuous
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