Receptor-interacting protein 140 as a co-repressor of Heat Shock Factor 1 regulates neuronal stress response

a, b Expression of RIP140, HSF1, P-HSF1, and HSPs in hippocampal neural cell line HT22 stressed at 41 or 43？°C. Quantified and normalized expression of RIP140 is shown under the corresponding blots. c Effects of RIP140 overexpression on iHSP70 mRNA expression at 41？°C (N？=？3). d Effects of RIP140 knockdown on iHSP70 mRNA expression at 41？°C (N？=？3). Results are presented as means？±？SEM, *p？<？0.05, **p？<？0.01 compared with HS control grou