AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells

a, b In mESCs and mouse embryos at different developmental stages, relative AIMP3 expression levels were assessed by qRT-PCR and western blot, respectively. E7.5 embryonic day 7.5, E10.5 embryonic day 10.5, E12.5 embryonic day 12.5, E14.5 embryonic day 14.5. c AIMP3 expression levels at the indicated times were determined by qRT-PCR during EB formation. Three independent experiments were performed for qRT-PCR, and results are expressed as the mean？±？SD. *p？<？0.05; ** p < 0.01; ***p？<？0.001; n.s., not significant (p > 0.05