SIRT1 induces epithelial-mesenchymal transition by promoting autophagic degradation of E-cadherin in melanoma cells

a A analysis of SIRT1 mRNA expression in primary melanoma (n？=？103) and metastatic melanoma (n？=？370). The RNA data were downloaded from the TCGA database. b, c Analysis of SIRT1 mRNA levels in primary and metastatic melanoma tissues from the {"type":"entrez-geo","attrs":{"text":"GSE46517","term_id":"46517"}}GSE46517 and {"type":"entrez-geo","attrs":{"text":"GSE8401","term_id":"8401"}}GSE8401 public data sets. d The expression of SIRT1 in the primary and metastatic melanoma tissues was analyzed by IHC. e The relationship between SIRT1 expression and the melanoma tissue type was evaluated using Pearson’s χ2 tes