How mutant p53 empowers Foxh1 fostering leukaemogenesis?

a Structural representation of human p53 core domain with hot spot mutation R273H. b Schematic representation of p53 domains including information on frequencies and types of mutations spanning across the entire human p53 sequence in acute amyloid leukaemia. Red picks indicate frequency of hotspot mutations; pink bars indicate position and type of missense mutations; purple bars indicate position and type of in frame deletions; red bars indicate position and type of nonsense mutations. Highest frequency and variety of mutations is observed in the p53 DNA binding domain. Source: COSMIC mutation databas