Berberine promotes the recruitment and activation of brown adipose tissue in mice and humans

a 18F-FDG PET/CT images in representative subject of the 10 before and after BBR intervention. b Mean cold-activated standard uptake value (SUV) in BAT regions. c The maximal SUV in BAT regions. d Detectable BAT volume. e BAT activity as reflected by 18F-FDG uptake. f The linear regression of BAT activity change percentage and body weight change percentage after BBR intervention. g The linear regression of BAT activity change percentage and HOMA-IR change percentage after BBR intervention. n？=？10. Data are expressed as mean？±？SEM. *P？<？0.05, **P？<？0.01, ***P？<？0.001 by paired Student’s t tes