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-  2017 

Prognostic Prediction of Oral Squamous Cell Carcinoma by E-Cadherin and N-Cadherin Expression in Overall Cells in Tumor Nests or Tumor Cells at the Invasive Front

DOI: 10.1007/s12307-017-0201-1

Keywords: Oral squamous cell carcinoma, Cadherin, Epithelial-mesenchymal transition, Multivariate analysis, Prognosis

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Abstract:

Representative views of immunohistochemical reactions for E-cadherin and N-cadherin in OSCC specimens. The expression of E-cadherin in each intensity grade from a strong (++), moderate (+), and weak (±) to no (?) signal (a-d), and the expression of N-cadherin in each intensity grade from no (?), a weak (±), and moderate (+) to a strong (++) signal (e-h). Arrows in (g) indicate a positive signal for N-cadherin in a tumor nest composed of OSCC cells with a squamous cell appearance. Original magnification ×20

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