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Bridging the gap between non-targeted stable isotope labeling and metabolic flux analysis

DOI: 10.1186/s40170-016-0150-z

Keywords: Stable isotope labeling, Metabolomics, Non-targeted, Flux analysis, Mass isotopomer distribution analysis, NTFD, Cancer, NAT8L, N-acetylaspartate

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Abstract:

Metabolism gained increasing interest for the understanding of diseases and to pinpoint therapeutic intervention points. However, classical metabolomics techniques only provide a very static view on metabolism. Metabolic flux analysis methods, on the other hand, are highly targeted and require detailed knowledge on metabolism beforehand

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