Spontaneous Hemopericardium Complicated with Hemothorax in a Patient Receiving Edoxaban Therapy: A Case Report

The introduction of non-vitamin K antagonists oral anticoagulants (NOACs) has been a major stride in stroke prevention for atrial fibrillation (AF). Edoxaban, a factor Xa inhibitor, has a remarkable safety profile and efficacy.1 Spontaneous hemopericardium is a rare complication of oral anticoagulant and had been reported in patients taking warfarin,2,3 dabigatran,4 rivaroxaban,5 and apixaban.6 To our knowledge, our case is the first to report a spontaneous hemopericardium in a patient taking edoxaban