|
OALib Journal期刊
ISSN: 2333-9721
费用：99美元
|
|
|
|
Optimization of 3-Pyrimidin-4-yl-oxazolidin-2-ones
as Allosteric and Mutant Specific Inhibitors of IDH1
DOI: 10.1021/acsmedchemlett.6b00334
Arne Mueller, B. Barry Touré, Brant Firestone, Fallon Lin, Fan S. Yang, Gang Liu, Gregg Chenail, Ina Dix, John Giraldes, Joseph D. Growney, Julia Dooley, Julian R. Levell, Kelly Slocum, Liping X. Zhou, Michael D. Jones, Ming Xu, Pascal D. Fortin, Raviraj Kulathila, Raymond Pagliarini, Remi Terranova, Simon van der Plas, Thomas Caferro, Trixie Wagner, Troy Smith, Ty Gould, Viraj Tyagi, Xiaoling Xie
Keywords: Mutant IDH1 inhibitor, allosteric inhibition, 2-HG, preclinical in vivo activity, 3-pyrimidin-4-yloxazolidin-2-one, chirality-defined potency
Abstract:
Full-Text
|
|
Contact Us
service@oalib.com QQ:3279437679 
WhatsApp +8615387084133
|
|
