A multi-labeled tree dissimilarity measure for comparing “clonal trees” of tumor progression

Graphical overview of tumor initiation and growth (left) and the corresponding clonal tree of tumor evolution (right). Sets of mutations providing proliferative advantage and driving the emergence of new clones are denoted as stars in the left and as sets of corresponding mutations in the right panel (e.g. red star from the left panel represents the set of mutations { M 1 , M 2 , M 3 } .) Vertex corresponding to the healthy cells is omitted as it would be non-informativ