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-  2017 

EXPRESSION OF MENIN IN THE HUMAN THYROID GLAND

DOI: 10.4183/aeb.2017.154

Keywords: menin, thyroid carcinoma, immunohistochemistry

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Abstract:

The expression of menin in the thyroid gland has long been debated. Animal models with targeted inactivation of menin in the thyroid gland have shown that its inactivation might play a role in the progression to a more aggressive type of cancer. Human studies are conflicting, some have identified mutations in the MEN1 gene in a sub-type of oncocytic thyroid carcinomas, while others have not identified a higher prevalence of thyroid cancer in MEN1 patients

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