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-  2019 

A 24-week double-blind placebo-controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer's disease and depressive symptoms

DOI: 10.1016/j.trci.2019.04.002

Keywords: Alzheimer's disease, Positive allosteric AMPA modulator, Glutamate, Depressive symptoms, Neuropsychiatric symptoms

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Abstract:

{"type":"entrez-protein","attrs":{"text":"S47445","term_id":"2132335","term_text":"pir||S47445"}}S47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid receptors that may emerge as a favorable candidate for the symptomatic treatment of cognitive and depressive disorders in patients suffering from Alzheimer's disease (AD) of mild to moderate severity and with depressive symptoms

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