All Title Author
Keywords Abstract

Publish in OALib Journal
ISSN: 2333-9721
APC: Only $99


Relative Articles

-  2019 

Serum Level of Total Lipids and Telomere Length in the Male Population: A Cross-Sectional Study

DOI: 10.1177/1557988319842973

Keywords: peripheral blood leukocytes, serum lipids concentrations, telomere length

Full-Text   Cite this paper   Add to My Lib


Telomeres contain TTAGGG (T; Thymine, A; Adenine and G; Guanine) repetitive sequences and are placed at the end of human chromosomes. Telomere dysfunction is implicated in some age-related and chronic diseases, but its association with total serum lipids and obesity is unknown. Our objective was to determine influenced of total serum lipids on leukocyte telomere lengths (TLs). Participants were selected by cluster sampling from 22 districts of Tehran. The questionnaires were completed by 500 subjects and after the initial assessment in terms of lifestyle, nutrition, home, and job, 300 healthy people, aged 25–40 years were finally selected. TLs and serum level of total lipids were measured by quantitative real-time PCR and the Phillips method, respectively. The average telomere length (T/S) and total lipids were 1.05 ± 0.3 mg/dl and 643.3 ± 70.8 mg/dl, respectively. We found that a one unit difference in the following parameters were associated with kilo base pair differences in TL: Age ?0.0002 (95% CI [?0.0022, ?0.0018]), BMI ?0.0019 (95% CI [?0.0003, ?0.0034]), TC 0.0001 (95% CI [?0.0006, ?0.0007]), TG ?0.0010 (95% CI [?0.0015, ?0.0004]), PL 0.0001 (95% CI [?0.0005, ?0.0007]), and TSL ?0.0003 (95% CI [?0.0008, 0.0001]). Spearman correlation analysis revealed an inverse relationship between TC (R = ?0.53; 95% CI [?0.61, ?0.44]), TG (R = ?0.50; 95% CI [?0.58, ?0.41]), PL (R = ?0.46; 95% CI [?0.54?0.36]), and TSL (R = ?0.63; 95% CI [?0.69, ?0.56]) with T/S. Our research suggests that the inverse relationship was found between TL and weight, BMI, age, and TSL which were associated with obesity. High serum lipids concentration may be associated with systemic inflammation and atherosclerosis and may lead to oxidative stress, resulting in telomere shortening


comments powered by Disqus

Contact Us


WhatsApp +8615387084133

WeChat 1538708413