Immune System Stimulation Reduces the Efficiency of Whole-Body Protein Deposition and Alters Muscle Fiber Characteristics in Growing Pigs

Disease reduces growth and protein retention in pigs. Protein retention is the balance between two energy-consuming processes in the body of pigs: protein synthesis and breakdown. Previous reports on the effects of disease on these components of protein metabolism and their consecutive effects on protein retention are inconsistent. In addition, limited information is available about the effects of disease on the composition of muscle fibers in pigs. Thus, we evaluated these parameters, since they help us to understand protein metabolism during disease in pigs. We used twelve gilts; five were used as a control and seven were made ill. Experimental diets were designed to supply nutrients that closely met the daily requirements of each group. Protein synthesis, protein breakdown, and protein retention were measured over 72 h. Pigs were then euthanized and various muscles were sampled. Our findings suggested that disease not only reduces protein retention by decreasing protein synthesis and protein breakdown, but also by reducing the efficiency of protein deposition. In other words, ill pigs synthesize more protein per unit of protein retention, compared to healthy pigs. In addition, disease reduces muscle mass and changes the composition of the muscle fibers. The latter might negatively affect pork quality