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-  2017 

On the computational complexity of the maximum parsimony reconciliation problem in the duplication-loss-coalescence model

DOI: 10.1186/s13015-017-0098-8

Keywords: Phylogenetic reconciliation, Duplication-loss-coalescence model, NP-hardness, APX-hardness

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Abstract:

Phylogenetic tree reconciliation is a widely-used method for inferring the evolutionary histories of genes and species. In the duplication-loss-coalescence (DLC) model, we seek a reconciliation that explains the incongruence between a gene and species tree using gene duplication, loss, and deep coalescence events. In the maximum parsimony framework, costs are associated with these event types and a reconciliation is sought that minimizes the total cost of the events required to map the gene tree onto the species tree

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