Effect of Some Antihypertensive Drugs on Alkaline Phosphatase and DNA of Mice SciDoc Publishers | Open Access | Science Journals | Media Partners

Various antihypertensive drugs are in a wide use for the treatment of hypertension. It is important to investigate the influences of chronic administration of these drugs on genomic DNA. So the objective of the present study was to elucidate the effects of chronic administration of some antihypertensive drugs e.g. amlodipine, atenolol and captopril on alkaline phosphatase(ALP) and genomic DNA in liver, spleen and kidney of Swiss albino mice. A total of 150 Swiss albino mice were divided into 10 groups (15 mice each): a control group and 3 groups to be treated by various doses of each of the three drugs. ALP was assayed in liver, spleen and kidney after drugs administration for 1; 3 and 6 months. The genotoxic effects of the three antihypertensive drugs were evaluated by RAPD-PCR technique. All studied drugs caused elevations in the activities of ALP in liver , spleen and kidney homogenates. Amlodipine induced DNA damage in the homogenates of liver, spleen and kidney . On the other hand, atenolol and captopril did not affect the genomic DNA. From our findings we can conclude that the chronic administration of the above antihypertensive drugs induce inflammation and amlodipine had toxic effect on the genomic DNA while atenolol and captopril had no apparent effects on DNA