Drug-eluting Stents in Premature Coronary Disease in Young People with Homozygous Familial Hypercholesterolemia and Prior Liver Transplant. A Report of Two Cases

FH is an autosomal dominant genetic disorder associated with elevated LDL-c levels, which may lead to premature cardiovascular disease. The early diagnosis of FH is important in order to prevent morbidity and mortality. FH is generally diagnosed based on clinical characteristics, family history, and serum cholesterol levels. The current Guidelines highlight the importance of lowering LDL-c levels in patients with FH. We report two patients with homozygous FH, in young people 14 and 15 years old, with clinical manifestations and severe hypercholesterolemia treated pharmacologically and with liver transplant. They presented acute coronary syndrome without ST elevation and severe CD treated successfully with implantation of drug-eluting stents