高龄下咽癌患者的手术治疗及围手术期处理
DOI: 10.3971/j.issn.1000-8578.2015.11.017
Keywords: 咽肿瘤,咽切除术,喉切除术,老年,Effect of Hypoxia on Expression of HIF-1α, GLUT-1 and MMP-2 in Laryngeal Carcinoma Cell Line Hep-2,Correlation Between Expression of SIX1, TGF-β and VEGF-C in Primarily Cultured Human Laryngeal Squamous Cell Carcinoma Cells,In vitro Investigation of Antitumor Efficacy of DpC on Head and Neck Cancer,Relationship between Local Recurrence and Anterior Commissure Involvement in Early Glottic Laryngocarcinoma after Radiofrequency Coblation,Clinical Efficacy and Prognosis of Concomitant Chemo-radiotherapy and Simple Radiotherapy on Patients with Advanced Laryngeal Cancer after Laryngectomy,Association between Brg1 Single Nucleotide Polymorphism and Laryngo Carcinoma,Anti-laryngocarcinoma Immunity of DC Vaccine which Silenced socs1 by siRNA,Expression and Significance of EGFR and TSLC1 in Different Laryngeal Lesions,Influence of Anti-apoptosis Induced by Recombinant survivin Adenovirus in Laryngeal Cacinoma Cells,Effects of Nimesulide on Expression of CD44 and MMP-7 in Nude Mice Transplanted Hep-2 Cell Line of Human Laryngeal Squamous Cell Carcinoma,Expression of MUC18 and Its Correlation with Counts of Microvessel and Lymph Vessel in Laryngeal Squamous Cell Carcinoma Tissues,Three Human Carcinoma Cell Lines with Different Sensitivity to Adenovirus Expressed E1A Gene,Effect of Simultaneously Blocking VEGF,hTERT and Bcl-xl Expression on Laryngeal Squamous Carcinoma
Abstract:
摘要 目的 探讨70岁以上高龄下咽癌患者安全有效的治疗方法。方法 回顾性分析安徽医科大学第一附属医院耳鼻咽喉头颈外科共85例70岁以上高龄下咽癌患者住院治疗的临床资料。手术治疗组68例，非手术治疗组17例。Kaplan-Meier法计算生存率，用卡方检验比较两组并发症发生率和拔管率。结果 手术组和非手术组患者5年生存率分别为38.2%（26/68）和5.9%（1/17），差异有统计学意义（P=0.005）。手术组中70~75岁年龄组和>75岁年龄组的5年生存率分别为38.6%（17/44）和37.5%（9/24），差异无统计学意义（P=0.26）。68例手术患者中45例行喉功能保留术，术后均恢复呼吸、吞咽和发音功能；23例未保留喉功能，术后均恢复呼吸和吞咽功能。手术患者并发症发生率为41.2%（28/68），70~75岁和>75岁年龄组的并发症发生率分别为38.6%（17/44）和45.8%（11/24），差异无统计学意义（P=0.56）。70~75岁和>75岁年龄组的拔管率分别为61.4%（27/44）和62.5%（15/24），差异无统计学意义（P=0.93）。结论 高龄下咽癌患者根据其全身状况及肿瘤的侵犯范围选择适当的手术方式是可行、安全有效的
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