调强放疗联合单药顺铂不同化疗方案同期治疗鼻咽癌的急性不良反应比较
DOI: 10.3971/j.issn.1000-8578.2015.03.016
Keywords: 鼻咽肿瘤,顺铂,放射疗法,高频,同期放化疗,急性不良反应,One Case Report of Ablation by Nano Knife on Unresectable Liver Metastases from Colon Cancer,Status and Relevant Causes of Cancer Pain Undertreatment,Effects of Treatment with Suicide Gene System HSV-TK/GCV Combined with Sonodynamic Therapy on Human Lung Cancer Cell NCI-446 in vitro,Combined Percutaneous Microwave Coagulation Therapy and S-1 in Treatment of Liver Metastases from Colon Cancer,Clinical Analysis of Whole Body Gamma Knife Combined with DP Regimen for Advanced Non-small Cell Lung Cancer,Influence and Clinical Significance of Thermochemotherapy on Expression of CD8+CD28+ T Subtype Cells in Peripheral Blood of Patients with Advanced Malignant Tumors,Treatment Effect and Prognostic Factors of Postoperative Therapy for 63 Patients with Renal Cell Carcinoma,Clinical Observation of Treatment with Yiqi Jianpi Decoction Combined with FOLFOX4 for Postoperation of Colorectal Cancer,Clinical Effects of Accelerator Linear Plus Gamma Knife Radiotherapy Combined with Concurrent DP Regimen Chemotherapy for Locally Advanced Non-small Cell Lung Cancer,Observation of Treating Advanced Breast Cancer with Ginsenoside Rg3 Combining with Capecitabine,Effect of Gemzar Combined with Electron Ray on Tumor Apoptosis in Nude Mice Xenograft of Human Pancreatic Carcinoma,Clinical Observation of Three Dimension Conformal Radiotherapy with Concurrent Chemoradiotherapy for Middle and Advanced Cervical Cancer,Dose Escalation of Topotecan Combined Whole Brain Radiotherapy for Brain Metastasis of Lung Cancer,Mechanism of Inhibition of ThermoChemotherapy on Cell Proliferation of Human Small Cell Lung Cancer
Abstract:
摘要 目的 比较无远处转移鼻咽癌（nasopharyngeal carcinoma, NPC）调强放疗（intensity-modulated radiotherapy，IMRT）联合单药顺铂每周（40mg/m2，1次/周）和每3周（80~100mg/m2，1次/3周）同期放化疗的急性不良反应和治疗前后的营养状况差异。方法 回顾分析45例IMRT联合单药顺铂同期化疗的非转移NPC患者临床资料，急性不良反应评估采用CTCAE 3.0标准，不良反应和营养状况统计分析采用t检验、卡方分析或精确概率法以及方差分析检验。结果 45例患者口干、咽痛、口腔黏膜炎、皮炎、恶心、呕吐及骨髓抑制3~4级不良反应发生率分别为6.7%、15.6%、28.9%、6.7%、8.9%、13.3%和22.2%。治疗后BW、BMI、TP、BUN、Cr、Na+、K+、Ca2+和Cl-变化的性别分层方差分析差异均无统计学意义（P＞0.05），ALB变化接近统计学意义。组内分析显示两组治疗后ALB、TP、Na+和Cl-均下降（P＜0.05），但顺铂每周组BW、BMI下降更明显（P＜0.05）。结论 治疗前后两组营养状况均有不同程度下降，顺铂每周组营养失衡较顺铂每3周组更普遍，但治疗前后两组变化无明显差异
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