早期前列腺癌不同治疗模式的疗效及生化复发的危险因素分析
DOI: 10.3971/j.issn.1000-8578.2015.06.015
Keywords: 2 Matched Case-control Investigation on Risk Factors of Gastric Cancer in Xianyou County,Interstitial Brachytherapy of Cervical Cancer,Association of Iodine Intake and Iodine-enriched Food with Risk of Thyroid Cancer: A Meta-analysis,Effect of Operation Incision Selection on Success rate of Sentinel Lymph Node Biopsy and Subcutaneous Hydrops in Breast Cancer,Review of Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Adjuvant Treatment of Non-small Cell Lung Cancer,Risk Factors Associated with Hematologic Toxicity in Concurrent Chemoradiotherapy and IMRT for Cervical Cancer,Review on Radiation Dose Fractionation on High-grade Glioma Patients,A Prospective Clinical Trial of Treatment Models on Malignant Ovarian Germ Cell Tumor Patients,Research Progress of Neoadjuvant Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma,Clinical Characteristics and Treatment Methods on Peripheral Primitive Neuroectodermal Tumors Patients,Relationship Between Bladder and Rectum Volume and Its Absorbed Dose of Radical Intensity Modulated Radiotherapy on Cervical Cancer
Abstract:
摘要 目的 探讨早期（T1~2N0M0）前列腺癌患者根治性手术或根治性放疗疗效对比及影响生化复发的相关因素。方法 回顾性分析新疆医科大学附属第一临床学院2004年4月至2012年4月间收治的269例早期前列腺癌根治术后患者的临床资料，采用多因素Logistic回归模型分析前列腺癌生化复发的危险因素。结果 269例前列腺癌患者中有97例经随访检测发生前列腺特异性抗原PSA（prostatespecific antigen）升高。单因素分析显示，肿瘤分期、Gleason评分、治疗前PSA水平、治疗前血红蛋白（hemoglobin，HGB）、肥胖与前列腺癌生化复发有关（P均＜0.05）；多因素分析显示，肿瘤分期、Gleason评分、治疗前PSA水平、肥胖是前列腺癌患者生化复发的独立高危因素（P均＜0.05）。两种不同的根治性治疗方式的生化复发率比较，总体累积生化复发率为36.0%，其中根治术组累积生化复发率为36.5%（23/63），根治放疗组为36.0%（74/206），两组生化复发的趋势较为一致。两种根治性治疗方式，治疗后第2年及第5年生化复发机率会增高。结论 T分期≥T2a、Gleason评分≥7 分、治疗前PSA≥10 ng/ml、肥胖的前列腺癌患者治疗后生化复发风险较高。对早期前列腺癌行根治性手术或根治性放疗可以达到相似的治疗效果，故可以根据患者的身体状况和意愿进行选择
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