泛素连接酶E3 Nedd4-like家族与癌症关系的研究进展
DOI: 10.3971/j.issn.1000-8578.2015.07.018
Keywords: 泛素连接酶E3,Nedd4-like家族,泛素化,癌症,Pathways of Lipid Metabolism and Their Associated Disorders in Cancer,Effect of Intensity Modulated Radiotherapy Combined with Hormonal Therapy on Fatigue in Patients with Locally Advanced Prostate Cancer,Cancer-related Fatigue in Advanced Lung Cancer Patients and Its Relationship with Inflammatory Cytokine in Serum,Discovery Approach and Economic Burden of Six Kinds of Common Cancers Patients in Beijing,Recent Progress in Small Nucleolar RNAs and Cancer,Relationship between Age,Gender and Symptoms in Advanced Cancer Patients,Experimental of Influence of Roxithromycin on Cancer Cachexia,Survey of Cancer Pain and Its Treatment
Abstract:
摘要 泛素蛋白酶体系统参与体内80%以上蛋白质的降解，调节体内细胞增殖，分化及存活，其功能紊乱可导致包括癌症在内的多种疾病。该系统中泛素连接酶E3 Nedd4-like家族已被证实在多种癌症发生、发展中发挥重要作用。泛素连接酶E3 Nedd4-like家族成员能够调节多种蛋白的泛素化、溶酶体及蛋白酶体降解作用及细胞核转位作用，因而影响着肿瘤发生过程中多条信号转导通路，如TGFβ、EGF、IGF、VEGF、SDF-1及TNFα通路。此外，该家族还可直接调节Smads、p53、KLF、RUNX及Jun等多种癌相关转录因子。由此可见，充分了解E3 Nedd4-like家族对癌症的潜在影响将有利于对生物标志物及药物靶点的认知与开发。现将该家族的主要特点、作用机制及在多种癌症中的表达情况作一综述
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