外周血循环肿瘤细胞对头颈恶性肿瘤患者临床病理特征和预后价值的Meta分析
DOI: 10.3971/j.issn.1000-8578.2018.18.0407
Keywords: A Meta-analysis,Meta-analysis of Efficacy and Safety of Jinlong Capsule Combined with Chemoradiotherapy on Liver Metastases,Comparison of Efficacy Between S-1 and Capecitabine/Fluorouracil on Advanced Colorectal Cancer: A Meta-analysis,Influence of GSTP-1 Genetic Variation on Prognosis of Postoperative Glioblastoma Patients Received Temozolomide Combined with Radiotherapy Regimens,Clinicopathologic Characteristics and Prognosis of De Novo Metastatic Breast Cancer Patients,Relation Between Metabolic Parameters of 18F-FDG PET/CT and Clinicopathological Features of Colorectal Cancer Patients,Prognostic and Clinicopathological Significance of PD-L1 Expression for Colorectal Cancer: A Meta-analysis,Value of 18F-FDG PET/CT in Evaluating Chemotherapeutic Effect of Diffuse Large B Cell Lymphoma Patients with Different CD5 Expression,Advances in Prognostic Value of Peripheral Blood Inflammatory Indexes in Non-small Cell Lung Cancer,Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients,Correlation Between Coke Oven Emissions and Death of Occupational Lung Cancer: A Meta-analysis,Cholesterol: A Predictor of Risk and Prognosis of Breast Cancer,Predictive Value of Preoperative Hematologic Inflammatory Markers in Prognostic of Glioma Patients
Abstract:
摘要 目的 通过Meta分析评价外周血中循环肿瘤细胞（circulating tumor cells, CTCs）检测与头颈恶性肿瘤临床病理特点和预后的关系。方法 利用计算机检索PubMed、EmBase、Cochrane图书馆、中国生物医学文献数据库（CMB）、中国知网全文数据库（CNKI）和万方数据库等，收集外周血中CTCs检测与头颈恶性肿瘤临床病理特点和预后关系的研究，检索时间为自建库至2018年3月。由2名研究者按照纳入与排除标准对文献进行筛选并提取数据和进行质量评价，采用Stata12.0软件进行Meta分析。结果 共有18篇文献（英文：17篇；中文：1篇）包含779例头颈恶性肿瘤患者纳入Meta分析，结果表明，与CTCs阴性组相比，外周血中CTCs阳性组患者的总生存期（OS）（P=0.006）、无病生存期（DFS）（P<0.001）和无进展生存期（PFS）（P=0.008）均显著缩短，且CTCs阳性组患者的复发风险显著高于CTCs阴性组，差异具有统计学意义（P=0.022）。同时，结果还提示外周血中CTCs阳性与头颈恶性肿瘤的T分期（P=0.028）、N分期（P=0.016）和TNM分期（P=0.024）呈显著正相关，而与患者年龄、性别和肿瘤组织学分级均无相关性。结论 外周血CTCs检测在头颈恶性肿瘤患者中具有显著的预后评估价值，CTCs阳性提示预后不良
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