TYMP基因多态性对结直肠癌患者R0切除术后辅助化疗疗效的影响
DOI: 10.3971/j.issn.1000-8578.2018.17.1667
Keywords: A Meta-analysis,Influence of GSTP-1 Genetic Variation on Prognosis of Postoperative Glioblastoma Patients Received Temozolomide Combined with Radiotherapy Regimens,Relation Between Metabolic Parameters of 18F-FDG PET/CT and Clinicopathological Features of Colorectal Cancer Patients,Prognostic and Clinicopathological Significance of PD-L1 Expression for Colorectal Cancer: A Meta-analysis,Composition and Laboratory Examination Characteristics of 187 Colorectal Cancer Patients with Schistosomiasis,Clinical Effect of Oral Nutritional Supplements in Patients with Colorectal Cancer After Emergency Surgery,Effects of NDUFA4 Overexpression on Growth of Human Colon Cancer Cells in vitro,Progress of Inhibiting Embden-Meyerhof-Parnas in Treatment of Colorectal Cancer,Established of Serum Diagnostic Model for Colorectal Cancer Patients Using MB-WCX and MALDI-TOF MS,Mechanism of Bacterial Biofilm Involved in Colorectal Carcinogenesis,Association of CYP1A1 and CYP1B1 Gene Polymorphisms with TypeⅠEndometrial Cancer in Chinese Women,Efficacy of IMRT Combined with Capecitabine Concurrent Chemotherapy and High Intensity Focused Ultrasound for Elderly Patients with Non-operatable Pancreatic Cancer,Recent Advances of Relationship Between miRNA-related SNPs and Lung Cancer Susceptibility,Expression and Correlation of Id-1, MMP-9 and LMVD in Colorectal Adenocarcinoma Tissues,Mortality Trend of Colorectal Cancer in Kunshan City, Jiangsu Province, 1981-2014
Abstract:
摘要 目的 探讨胸苷磷酸化酶（thymidine phosphorylase, TYMP）基因变异是否对R0术后结直肠癌患者接受辅助化疗疗效有影响。方法 纳入198例术后接受辅助化疗的结直肠癌患者。收集患者外周血及术后癌组织标本分别用来进行TYMP基因5633C>T位点基因分型及TYMP基因表达测定。通过不同的分析方法分析该位点和其他变量的关系。Real-time PCR分析该位点不同基因型患者的TYMP mRNA表达水平。结果 TYMP基因5633C>T位点在CRC患者中的基因型分布频率为CC型126例（63.64%），CT型61例（30.81%），TT型11例（5.55%），最小等位基因频率为0.21，三种基因型分布频率符合哈迪温伯格平衡（P=0.323）。不同基因型患者基线资料均衡，预后分析上将CT/TT基因型合并。单变量生存分析结果显示：野生型的CC型患者OS较差，显著低于携带突变基因的CT型和TT型患者，差异有统计学意义（P=0.009）。多变量Cox模型校正之后发现CC基因型对OS有独立的影响（P=0.015）。另外，进一步在87例癌组织标本的mRNA表达分析中发现，突变的CT或TT型患者相对于野生型的CC型患者，癌组织中TYMP mRNA表达明显较高，差异有统计学意义（P=0.019）。结论 TYMP基因5633C>T位点可能通过影响TYMPmRNA的表达从而影响接受含卡培他滨辅助化疗方案的CRC患者的预后
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