恩度微量泵入与腹腔注射联合表阿霉素治疗小鼠乳腺癌的疗效对比观察
DOI: 10.3971/j.issn.1000-8578.2018.17.1349
Keywords: A Predictor of Risk and Prognosis of Breast Cancer,Tanshinone ⅡA Enhances Chemosensitivity of Breast Cancer Cells to Doxorubicin and Related Mechanism,In Situ Hybridization Status of 568 Cases of HER2 Equivocal Breast Cancer,Apatinib Suppresses Proliferation and Induced Apoptosis of Human Breast Cancer Cell Line MDA-MB-231 Through Glycolytic Inhibition,Progress of Whole Exon Sequencing in Pathogenesis and Diagnosis of Breast Cancer,Feedback Activation of STAT3 Confers Resistance of HER2-positive Breast Cancer Cells to Lapatinib,Influence of NRP-1 Monoclonal Antibody on Growth of Breast Cancer Xenografts in Nude Mouse,Expression of Circular RNA ciRS-7 and Its Effect on Invasion and Migration of Triplenegative reast Cancer Cells,Breast Metastasis of Primary Pulmonary Adenocarcinoma: A Report of Two Cases and Literature Review
Abstract:
摘要 目的 比较恩度微量泵入或腹腔注射联合表阿霉素对小鼠乳腺癌的疗效。方法 建立乳腺癌4T1细胞的BALB/c小鼠移植瘤模型，随机分为空白对照组（0.9%NaCl, ip）、标准对照组（EPI, ip）及4个实验组：（1）rhES（ip）+EPI（ip）；（2）rhES（pump）+EPI（ip）；（3）rhES（ip）；（4）rhES（pump）。监测肿瘤大小和小鼠体重，治疗第10天行小动物活体成像，治疗结束后采用免疫组织化学法测定瘤内血小板-内皮细胞黏附分子（CD31）的表达。结果 恩度单药持续微量泵入（7 mg/（kg.d））疗效显著优于腹腔注射（P=0.01）；恩度持续微量泵入联合表阿霉素与双药联合腹腔注射疗效相当（P>0.05），但前者不良反应略低。结论 恩度微量泵入联合表阿霉素治疗小鼠乳腺癌疗效与传统静脉滴注相当，为开展乳腺癌患者携泵回家治疗的可能性提供了实验依据，但还需要进一步的临床试验加以证实
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