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-  2019 

CDK4/6抑制剂的联合治疗模式

DOI: 10.3971/j.issn.1000-8578.2019.18.0906

Keywords: A Scientometric Analysis,Efficacy of Definitive External-beam Radiotherapy Versus Radical Prostatectomy on Clinically Localized High-risk Prostate Cancer Patients: A Retrospective Study,A Case Report of Four Primary Malignant Tumors,Oncolytic Adenovirus RCA-TERT-Ad35 Carrying Human Telomerase Reverse Transcriptase Promoter Targets Breast Cancer Stem Cells,Research Progress of Intestinal Microbiota and Immune Checkpoint Inhibitors,Advances in Role of Cyclooxygenase 2 in Development and Progression of Cancer,Dedifferentiated Liposarcoma of Testis: A Case Report and Literature Review,A Comprehensive Review of Androgen Deprivation Therapy and Immunotherapy on Prostate Cancer,Diffusion-weighted Magnetic Resonance Imaging Evaluates Salivary Gland Function Damage in Nasopharyngeal Carcinoma Patients Treated with Intensity-modulated Radiation Therapy,Research Advances on Effect of Adipose-derived Stem Cells on Biological Characteristics of Breast Cancer

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Abstract:

摘要 细胞周期素依赖激酶(CDKs)抑制剂联合内分泌治疗已经用于晚期乳腺癌的治疗。除了内分泌治疗,CDK4/6抑制剂还可以联合表皮生长因子受体(EGFR)抑制剂、磷脂酰肌醇-3激酶(PI3K)/哺乳动物雷帕霉素靶蛋白(mTOR)抑制剂、化学治疗、免疫治疗、分子靶向治疗和其他治疗。联合治疗模式克服了CDK4/6抑制剂的耐药并提高了临床疗效,开启了肿瘤精准治疗的一扇新窗口

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