早期宫颈癌淋巴结转移的高危因素分析及列线图预测模型的构建
DOI: 10.3971/j.issn.1000-8578.2019.18.0942
Keywords: A Meta-analysis,Risk Factors of Pathological Upstaging for Patients with Clinical T2N0M0 Esophageal Squamous Cell Carcinoma,Comparison of Survival and Postoperative Complication of Stage Ⅰb2-Ⅱa2 Cervical Cancer Patients Among Three Kinds of Therapeutic Regimens,Expression and Correlation of miR-135a-5p, GATA3 and STAT3 in Cervical Cancer,Tumor-associated Macrophages Promote Invasion and Metastasis of Cervical Cancer,Indocyanine Green Angiography for Preserving Ureteral Branch of Uterine Artery in Radical Hysterectomy,Effect of Overexpression of Follistatin-like Protein 1 on Downstream Genes in Cervical Cancer and Bioinformatic Analysis of Downstream Genes,Correlation of FoxO3 Gene with Clinicopathological Features and Prognosis of Bladder Cancer Patients,miR-198 Targets MAPK1 to Regulate Proliferation, Apoptosis and Invasion of Cervical Cancer HeLa Cells,δ-tocotrienol Inhibits Proliferation of Cervical Carcinoma Cells Through Upregulating MicroRNA-34a,Effect of High Energy X-rays at Different Dose Rates on Biological Effects of Cervical Cancer HeLa Cells,Correlation of Nerve Growth Factor and Its Receptors Expression with Perineural Invasion in Early-stage Cervical Cancer,Effect of High-mobility Group Box-1 on Expression of Stem Cell Markers OCT4, Sox2 and Nanog in Cervical Carcinoma,HPV16-E6 Influences Growth and Apoptosis of Cervical Cancer Cells Through Upregulation of MIF
Abstract:
摘要 目的 探讨临床病理特征与早期宫颈癌淋巴结转移的关系，同时建立列线图模型预测只行根治性手术而未进行淋巴结清扫的早期宫颈癌患者淋巴结转移情况。方法 回顾性收集福建医科大学附属第一医院妇科432例行子宫切除及淋巴结清扫术并经病理组织学确诊的早期宫颈癌患者术后临床病理资料。运用Logistic回归分析确定早期宫颈癌淋巴结转移的高危因素。建立预测早期宫颈癌淋巴结转移风险的列线图模型，分别用一致性系数（C-index）和校准曲线评估模型的预测性能和符合度。结果 432例早期宫颈癌患者中，有84例患者出现转移，阳性率19.4%。多因素分析显示肿瘤最大径>3 cm、宫旁浸润、淋巴血管间质浸润是早期宫颈癌患者淋巴结转移的独立危险因素，其OR分别为1.98（95%CI:1.17~3.34）、2.64（95%CI: 1.28~5.44）、4.77（95%CI: 2.60~8.75）。用于预测淋巴结转移风险的列线图的准确度为0.687。结论 基于肿瘤最大径>3 cm、宫旁浸润和淋巴血管间质浸润构建的列线图，可用于指导只行根治性手术而未行淋巴结清扫的早期宫颈癌患者的进一步治疗
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