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DOI: 10.3971/j.issn.1000-8578.2018.18.0167
Keywords: A Retrospective Study,Application of PSMA PET/CT Specific Molecular Imaging in Diagnosis of Non-prostate Cancer,Bone Metastasis in Children with Metanephric Adenosarcoma: A Case Report and Literature Review#br#,A Comprehensive Review of Androgen Deprivation Therapy and Immunotherapy on Prostate Cancer,Application of Superb Micro-vascular Imaging Technology in Guiding Accurately Targeted Biopsy of Prostate Cancer,Efficacy and Prognostic Factors of Docetaxel Rechallenge on Metastatic Castrationresistant Prostate Cancer Patients,Advances in Molecular Mechanisms of Early Bone Metastasis,A Comparison Study Between Low-dose Oxycodone/Acetaminophen Tablet and Codeine on Moderate Bone Metastasis Cancer Pain,Advanes of Driving Genes in Bone Metastases from Lung Cancer,Best Imaging Time of Near-infrared Fluorescence Imaging for Prostate Cancer Xenografts,Efficacy and Prognostic Factors of Docetaxel Combined with ADT on Metastatic Hormone-sensitive Prostate Cancer Patients,The Second Primary Cancers in Patients with Prostate Cancer: An Update,Effects of Long Non-coding RNA-MALAT1 on Proliferation and Apoptosis of Prostate Cancer Cells,Tumor-associated Macrophages Promote Invasion and Metastasis of Cervical Cancer,Qualitative Diagnostic Value of Different Apparent Diffusion Coefficients on Metastatic Pelvic Lymph Nodes in Prostate Cancer
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摘要 前列腺癌（prostate cancer, PCa）转移中大约80%是发生骨转移，是造成患者死亡的主要原因。前列腺癌骨转移主要呈现成骨和破骨混合性损伤。然而，诱发肿瘤细胞转移到骨以及引起混合样病变的机制仍不十分清楚。宿主微环境与前列腺癌细胞间的相互作用是其中一个重要原因。本文主要讨论宿主微环境如何影响前列腺癌骨转移各个阶段的发生及其中的机制，探讨多种细胞因子、分泌蛋白、微环境中的免疫细胞、成骨细胞、破骨细胞等分泌的因子在前列腺癌骨转移中的重要作用
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