细胞膜磷脂与肿瘤侵袭、转移及靶向治疗的相关性研究进展
DOI: 10.3971/j.issn.1000-8578.2015.06.022
Keywords: 膜磷脂,肿瘤转移,靶向治疗,Effect of Hormones from Adrenal Gland on Breast Cancer Metastasis in Mice,Effects of Vascular Endothelial Cells on Invasion of Glioma Cells via Notch Signal Pathway,Association of Structure and Functions of Lysine Methyltransferase SET8 with Tumorigenesis,MicroRNAs Expression in Benign and Malignant Pleural Effusion,Effect of Store-operated Calcium Entry on Tumor Metastasis,Role of Pro-apoptotic Protein Siva1 in Tumor,Review on Enrichment and Detection of Circulating Tumor Cells,Effect of AMF/AMFR on Cell Invasion and Metastasis of Malignant Tumors,Effect of Exogenous AES on Malignant Behaviors of Colorectal Cancer Cells,Contribution of Epithelial-mesenchymal Transition to Vasculogenic Mimicry,Effects of Lentiviral-Mediated Foxp1 siRNA to Proliferation, Apoptosis and Migration of Hepatoma Carcinoma Cell,Progress of Zoledronic Acid on Antiangiogenesis Effects,Analysis of Gastrin-releasng peptide(GRP) and Its Receptor in Forecasting Metastasis of Small Cell Lung Cancer
Abstract:
摘要 侵袭和转移是肿瘤进展的标志，是肿瘤临床治疗的难题及肿瘤患者死亡的主要原因。磷脂是生物膜的重要物质基础，参与肿瘤细胞增殖、运动、黏附、凋亡、信号转导、细胞周期调节等活动。本文对膜磷脂在肿瘤侵袭、转移、靶向治疗中的作用研究进展进行了综述。细胞膜磷脂成分及分布、磷脂代谢产物、磷脂酶及磷脂结合蛋白在肿瘤细胞膜流动性、黏附、凋亡、增殖、侵袭、转移、血管及淋巴管形成中具有重要作用，以细胞膜磷脂及其代谢产物为靶点治疗恶性肿瘤具有广阔前景
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