PD1/PD-L1激活促进癌症发生、发展和转移的研究进展
DOI: 10.3971/j.issn.1000-8578.2017.17.0087
Keywords: One Case Report and Literature Review,Intractable Cancer Pain of Bone Metastasis from Parotid Gland Cancer Is Treated by High Intensity Focused Ultrasound: A Case Report,Postoperative Gastric Adenocarinoma Metastasis to Gingiva: A Case Report,Thoracic Vertebrae Metastasis as First Symptom of Clear Cell Carcinoma of Thyroid Gland: A Case Report,Relationship Between EGFR Mutation and Brain Metastasis in Non-small Cell Lung Cancer,Effect of Hormones from Adrenal Gland on Breast Cancer Metastasis in Mice,Mechanism of Ibuprofen Regulating Migration and Invasion of Liver Cancer QGY-7703 Cells Through PI3K/Akt/mTOR Signaling Pathway,Expression and Correlation of Id-1, MMP-9 and LMVD in Colorectal Adenocarcinoma Tissues,One Case Report of Ablation by Nano Knife on Unresectable Liver Metastases from Colon Cancer,Anti-tumor Effect of Dentritic Cells Vaccine Sensitized by GnRH/M2 and mGM-CSF/βhCG Fusion Proteins on Prostatic Cancer in Mice,Correlation Between Skull Base Invasion and Bone Metastases in Locally Advanced Nasopharyngeal Carcinoma Patients,Apatinib Treatment for Primary Liver Cancer with Lung Metastasis: A Case Report,UGCG is Involved in Oxaliplatin Resistance Mechanism of Human Colon Cancer Through Regulating MDR1/P-gp Expression,Prognostic Value of Circulating Tumor Cells for Metastatic Prostate Cancer: A Metaanalysis
Abstract:
摘要 程序性死亡受体1（PD1）和程序性死亡配体1（PD-L1）是重要的负性免疫调节因子。T细胞表面PD1受体与肿瘤细胞表面表达的PD-L1配体结合，向细胞内传递调控信号，抑制T细胞活化与增殖，从而介导肿瘤细胞的免疫逃逸及对常规放化疗的抵抗。近年来，针对PD1/PD-L1的单克隆抗体靶向药物在非小细胞肺癌和黑色素瘤等实体肿瘤治疗中均取得了较好的疗效，显著改善了部分肿瘤患者的临床进展和不良预后。本文综述了PD1/PD-L1在肿瘤发生、发展和转移中的重要作用以及PD1/ PD-L1抗体应用于肿瘤免疫治疗中的最新进展
Full-Text
